Mohammad Taimur Hossain Talukdar1, Md. Saiful Islam2, Dabashis Patowary3
Mustaqim Billah4, Md. Mokhles Uddin Ahmed5
- Associate Professor, Department of Oncology, North East Medical College, Sylhet
- Associate Professor, Department of radiology and imaging, North East Medical College, Sylhet
- Associate Professor, Department of radiology and imaging, North East Medical College, Sylhet
- Associate Professor, Department of oncology, North East Medical College, Sylhet
- Professor, Department of radiology and imaging, BICH & Dhaka Shisu Hospital
- Professor, Department of oncology, North East Medical College, Sylhet
Abstract
Brain metastases are the most common intracranial tumors in adult, accounting for more than one half of all intracranial tumors in adult. The most common types of cancer that causes metastasis to brain are cancers of lung, breast, skin(melanoma), colon, kidney and thyroid gland. Supportive care for multiple brain metastases was the only viable option available till the first half of 20th century. The primary approaches to the treatment of brain metastases include surgery, stereotactic radiosurgery(SRS) and whole brain radiation therapy (WBRT). Whole brain radiation therapy has traditionally been considered the standard treatment for patients with cerebral metastases, particularly multiple brain metastases. This prospective observational study was conducted in the Oncology Department of North East Medical College Hospital during the period from July 2016 to June 2019. Thirty six patients over 18 years old presented with symptomatic inoperable brain metastases regardless of primary & previously untreated for brain metastasis were included in this study. Histology of the primary tumors were collected from the documents. Among the 36 cases, males predominated (66.67%), lung was commonest primary site. CT scan and/or MRI of brain done in all the cases before treatment. The radiation was given by 6MEV photon from Linac using conventional 2D, 3DCRT and VMAT planning. Dose was 30 Gys in 10 fractions. Median survival after cranial irradiation was four months(range 1-24 months).
Key Words: Microbial keratitis, predisposing factors, clinical profile