Begum Nazmus Sama Shimu1, Md. Saiful Islam Bhuiyan2, Syeda Umme Fahmida Malik3,
Mushfika Rahman Chowdhury4, Tawhida Rahman Chowdhury5, Md. Kamrul Hossain Azad6
1. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet.
2. Assistant Professor, Department of Psychiatry, Mainamati Medical College, Comilla.
3. Associate Professor & Head, Department of Biochemistry, North East Medical College, Sylhet.
4. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet.
5. Assistant Professor, Department of Biochemistry, City Medical College, Gazipur.
6. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet.
Abstract
Schizophrenia is a complex disease and drugs those are being used currently for its management have potential side effects. For this reason maintenance of treatment becoming difficult. So this comparative study was carried out between group-A and group-B to evaluate biochemical parameters in schizophrenic patients treated with olanzapine and risperidone respectively for short term (6 months to 3 years) and long term (more than 3 years). This cross sectional comparative study was carried out in the Department of Biochemistry in collaboration with the Department of Psychiatry, Sylhet MAG Osmani Medical College Hospital, Sylhet from 1st July 2012 to 30th June 2013. Sixty schizophrenic patients were divided into two groups. Group A(n=38) patients were treated with Olanzapine and Group B (n=22) patients with Risperidone. Both groups were again subdivided into two sub-groups according to duration of trearment (short term, 6months-3 years and long term, 3 years). Biochemical parameters of each group were estimated and analysed on the basis of duration of treatment. Serum glucose, cholesterol, triglyceride, ALT, alkaline phosphatase, creatinine and uric acid level were measured. There was significant increase in mean fasting blood glucose, serum triglyceride and serum alkaline phosphatase level in both groups after prolonged use of olanzapine and risperidone. But no significant change was found in other biochemical parameters in any treatment group. It may be concluded that, fasting blood glucose, serum triglyceride and serum alkaline phosphatase level increase in schizophrenic patients treated for long term with atypical antipsychotics such as olanzapine and risperidone.
Key words: Schizophrenia, Olanzapine, Risperidone