Syeda Umme Fahmida Malik1, Begum Najmus Sama Shimu2, Mushfika Rahman Chowdhury3,
Mahin Sultana4, Md. Kamrul Husain Azad5
1. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
2. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
3. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
4. Associate Professor, Department of Anatomy, North East Medical College, Sylhet
5. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
Abstract
Obesity and dyslipidemia are emerging as major health challenges in South Asian countries. Insulin resistance and abnormal lipid profile are the risk factors for cardiovascular disease in obesity. Up to 92% of people with Type 2 diabetes demonstrate insulin resistance (IR). Because of the occurrence of type 2 diabetes, dyslipidemia and other cardiovascular morbidities at a lower range of body mass index (BMI), it is proposed that cut offs for both measures of obesity should be lower (BMI 23-24.9 kg/m2 for overweight and 25kg/m2 for obesity) for South Asians. It is common to find characteristic changes from the normal lipid and lipoprotein pattern in insulin resistance individuals. Blood insulin level have been found to be positively correlated with plasma total cholesterol and TG; and inversely correlated with HDL-C. The TG/HDL-C ratio has been advocated as a simple clinical indicator of insulin resistance. Aim of this study is to determine the level of insulin resistance and lipid profile in Bangladeshi adults. After exclusion of other endocrine disease (n = 52) the remaining patient were classified as IR > 2 Insulin Resistance (n = 174) & IR < 2 Insulin sensitive (n = 124) The data showed TC, TG. LDL-C were statistically significant at p < 0.05 level in IR than control. Fasting blood sugar, HOMA-IR by homeostatic modeling results are expressed as means± SD. Logistic regression models TG/HDL-C at a cut-off point of >2 in predicting insulin resistance(HOMA-IR>2) in all patients. Our research showed that serum lipoprotein ratios had a significant positive correlation with IR. To clarify the relationship of the changes in insulin resistance, body weight and lipid profile we performed this study in Bangladeshi adults.
Key words: TC: Total cholesterol, LDL: Low density Lipoprotein, VLDL: Very low density lipoprotein, HDL: High density lipoprotein, TG: Triglyceride, HOMA: Homeostatic model Assessment.