Smita Roy¹, Parimol Kishore Dev², Begum Nazmus Sama Shimu, Nasrin Akter, Mushfika Rahman Chowdhury, Umme Fahmida Malik
1. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet.
2. Associate Professor, Department of Anaesthesiology, Jalalabad Ragib Rabeya Medical College, Sylhet
3. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
4. Associate Professor, Department of Pharmacology, North East Medical College, Sylhet
5. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
6. Professor and Head, Department of Biochemistry, North East Medical College, Sylhet
Abstract
Obesity and insulin resistance are closely linked to various metabolic disorders, including type 2 diabetes and cardiovascular diseases. Understanding the relationship between body mass index (BMI) and insulin resistance is crucial for identifving individuals at higher risk for these conditions. This study aims to explore the impact of BMI on insulin resistance. This cross-sectional study was conducted to explore the relationship between BMI and insulin resistance in patients with metabolic syndrome. The age ranged 30-70 years were recruited and the participants diagnosed with metabolic syndrome based on ATP III/IDF criteria. Exclusion criteria included diabetes, endocrine disorders, chronic illnesses affecting metabolism, and pregnancy. Anthropometric and fasting blood measurements were taken to assess BMI, fasting glucose. HbAlc, and lipid profile. Specifically, fasting glucose ranged from 88-115 mg/dl. in normal-weight participants, 95-130 mg/dl. in overweight participants, and 105-140 mg/dl. in obese participants. As BMI increased, fasting glucose. HbAlc, and triglyceride levels rise, while HDL-C levels declined. The prevalence of insulin resistance was notably higher in overweight and obese participants, emphasizing the critical role of obesity in the development of insulin resistance.
Key Words: BMI, Insulin Resistance, Metabolic Syndrome, HbAlc