Tasnim Ashraf1, Jibon K Paul2, Liton Ahmed3, Md. Hasanuzzman Mashhud4, Mizanur Rahman5, Saleha Afrin Bristi6
1. Assistant Professor, Department of Anaesthesia, Analgesia & ICU, North East Medical College & Hospital.
2. Associate Professor, Department of Anesthesiology, North East Medical college, Sylhet, Bangladesh
3. Assistant Professor, Department of Anesthesiology, North East Medical college, Sylhet, Bangladesh.
4. Assistant Professor, Department of Anesthesiology, North East Medical college, Sylhet, Bangladesh
5. Medical officer, Divisional police Hospital, Sylhet. Bangladesh
6. Medical Officer, Department Of cardiology, North East Medical college, Sylhet, Bangladesh
Abstract
Hypotension is most common intraoperative complication during spinal anaesthesia for caesarean section which has detrimental effects on both mother and fetus. To assess the Intravenous Ondansetron with Placebo for Attenuation of Spinal Induced Hypotension. A Prospective Randomised Interventional Study of Intravenous Ondansetron with Placebo for Attenuation of Spinal Induced Hypotension 70 patients belonging to ASA Class-I and II, aged 20-45 years, weight 40-60 kilograms, undergoing cesarean delivery under spinal anesthesia were included in this study. Patient with history of Pregnancy-Induced Hypertension (PIH), convulsion, compromised airway or morbid obesity and required general anaesthesia for supplementation were excluded from study, Group O (n=35) received 6mg ondansetron in normal saline intravenously; total volume made 10ml. Group S (n=35) received 10ml normal saline intravenously. Blood pressure and heart rate were checked every 5minutes till the end of the surgery. Data was analyzed by chi square test. Systolic, diastolic and mean blood pressure were found to be higher in group O as compare to group S at different time intervals (P value < 0.05). In group O 67% patients required vasopressors whereas in group S 91% patients required vasopressors. Incidence of nausea and vomiting is less in group O (P value=0.001). Conclusion: Prophylactic intravenous ondansetron causes reduced incidence of hypotension, requirement of vasopressors and Post-operative nausea-vomiting during spinal anaesthesia. Prophylactic ondansetron use is associated with less incidence of nausea and vomiting in spinal anesthesia in healthy pregnant patient.
Key Words: Hypotension, Ondensetron, Spinal Anesthesia, Bupivacaine.