Saima Haque Lisa1, Qazi Shamima Akhter2, Mahedy Ahmed Munna3,
Choudhury Rifat Jahan4, Nusrath Jahan Chowdhury5
Choudhury Rifat Jahan4, Nusrath Jahan Chowdhury5
1. Assistant Professor, Department of Physiology, Park View Medical College, Sylhet.
2. Professor & Head, Department of Physiology, Dhaka Medical College, Dhaka.
3. Assistant Professor, Department of Anesthesiology, Park View Medical College, Sylhet.
4. Associate Professor & Head, Department of Physiology, Park View Medical College, Sylhet.
5. Assistant Professor, Department of Physiology, Park View Medical College, Sylhet.
Abstract
Preeclampsia is a multifactorial disease of unknown etiology and is associated with oxidative stress. Some studies observed that exposure to toxic metals may contribute to the development of preeclampsia To assess the serum lead (Pb) level and its relation with blood pressure and urinary protein level in preeclampsia. Methods: This cross sectional study was conducted in the Department of Physiology. Dhaka Medical College, Dhaka from July 2016 to June 2017. Thirty subjects with preeclampsia age ranging from 18 to 40 years were considered as the study group and 30 aged matched healthy pregnant women were considered as control group for comparison. The subjects were selected from Department of Obstetrics and Gynecology of Dhaka Medical College hospital, Dhaka. Serum lead (Pb) level was estimated in the Department of Soil, Water and Environment of University of Dhaka. For statistical analysis, unpaired Students “t” test and Pearson’s correlation coefficient (r) test were performed. In this study serum lead level was significantly (p < 0.001) higher in preeclampsia patients as compared to controls. Serum lead level showed positive correlations with systolic &diastolic blood pressure and urinary protein level. This study concluded that serum lead level increases and is positively related with blood pressure and urinary protein level. Therefore, estimation of serum lead level in early pregnancy might be useful for prediction of future risk of developing preeclampsia.
Key Words: Preeclampsia, Lead, Blood pressure.