Md. Siddiqur Rahman1, Md. Abdul Monaf2, Nazrul Islam Bhuian3, Mst. Suchana Nazrin4,
Fahmi Iqbal Rabbi5, Avijit Das6, Yeasmin Nahar7
1. Associate Professor, Department of Urology; North East Medical College, Sylhet
2. Associate Professor, Department of Urology; North East Medical College, Sylhet
3. Assistant Professor, Department of Urology; Bangladesh Medical College, Dhaka
4. Associate Professor, Department of Pathology; North East Medical College, Sylhet
5. Assistant Professor, Department of Microbiology; North East Medical College, Sylhet
6. Associate Professor, Department of Microbiology; North East Medical College, Sylhet
7. Assistant Professor, Department of Microbiology; North East Medical College, Sylhet
Abstract
Micropenis is defined as a stretched penile length 2.5 standard deviations less than the mean for age without the presence of any other penile anomalies, such as hypospadias. The term refers to a specific disorder that has a known set of causative factors and defined treatment modalities. The purpose of this study was to determine the effect of hormonal therapy on the gonadal response and penile growth in children who presented with micropenis. Children (<18 years) who met the criteria for micropenis were included in this study. Children more than 11 years old were treated using a standard protocol of 1,500 to 2,000 IU human chorionic gonadotrophin administrated intramuscularly, once per week, for 6 weeks. Children less than 11 years old were treated with parenteral testosterone enanthate 25 mg once a month for 3 months. Response was evaluated in terms of change in testosterone levels and size of penis. Serum testosterone levels at baseline and after 8 weeks of hormonal treatment were <20 and 445.35 ng/mL, respectively (P<0.0001) in all children more than 11 years old. Stretched penile length after hormonal treatment increased from 15.54 to 38.26 mm in children less than 11 years old and from 28.42 to 65.24 mm in children more than 11 years old (P < 0.001). The results of isolated micropenis with hormone treatment to increase in penile length are promising.
Keywords: Children, human chorionic gonadotropin, micropenis, testosterone.