CM Reza Qureshi Forhad1, Manojit Majumder2, Fatma M Khan3, Siddhartha Paul4,
Md. Zahidur Rahman5, Mahabub Ul Alom Sumon6
1. Assistant Professor, Biochemistry, Tairunnessa Memorial Medical College, Gazipur
2. Assistant Professor, Biochemistry, Sylhet M.A.G Osmani Medical College, Sylhet
3. Associate Professor, Biochemistry, Tairunnessa Memorial Medical College, Gazipur
4. Associate Professor, Psychiatry, North East Medical College, Sylhet
5. Secretary, The State Medical Faculty of Bangladesh, Dhaka
6. Assistant Professor, Biochemistry, Jalalabad Ragib-Rabeya Medical College, Sylhet
.Abstract
Introduction: Nearly one third of the global population is infected with Mycobacterium tuberculosis and thus at risk of developing the disease. Biomarkers are able to assess several areas of clinical management for both adults and children with TB such as disease activity and extent, treatment effect (response to treatment), treatment outcome (cure), disease relapse, anticipated poor clinical outcomes (so that treatment can be modified appropriately) and end-points of novel anti-TB drugs. Serum CRP has been reported to increase significantly in patients with active tuberculosis. Significant decrease in serum CRP concentration was noted in patient of pulmonary tuberculosis during the first month of treatment which approached to normal level by three months of treatment. The present work is designed to explore the association of C-reactive protein in patients with pulmonary tuberculosis and to assess the treatment response.
Material and Methods: This prospective study was conducted in 2010, at the Department of Biochemistry, Sylhet MAG Osmani Medical College, and DOT centre, MAG Osmani Medical College Hospital, Sylhet. Blood samples were tested for C-reactive protein. After two months of starting anti-tubercular therapy when patient came for follow up again laboratory data were recorded and blood sample was collected for ESR and C-reactive protein. CRP was also evaluated only once, in the group of healthy control.
Result: In our study there is no significant difference in age of cases & controls. Serum level of C-reactive protein and ESR were increased in our study cases. There was a significant positive correlation between ESR and serum C-reactive protein in TB patient.