Syeda Umme Fahmida Malik1, Gulshan Ara Begum2, Md. Kamrul Hussain Azad3,
Begum Nazmus Sama Shimu4
1. Associate Professor, Biochemistry, North East Medical College, Sylhet
2. Associate Professor, Biochemistry, Jalalabad Ragib-Rabeya Medical College, Sylhet
3. Assistant Professor, Biochemistry, North East Medical College, Sylhet
4. Lecturer, Biochemistry, North East Medical College, Sylhet
Abstract
Obesity and dyslipidemia are emerging as major public health challenges in South Asian countries. The prevalence of obesity is more in urban areas than rural, and women are more affected than men. Obesity in South Asians has characteristic features: high prevalence of abdominal obesity, with more intra-abdominal and truncal subcutaneous adiposity than white Caucasians. There is greater accumulation of fat at “ectopic” sites, namely the liver and skeletal muscles. All these features lead to higher magnitude of insulin resistance, including atherogenic dyslipidemia. Because of the occurrence of type 2 diabetes, dyslipidemia and other cardiovascular morbidities at a lower range of body mass index (BMI) andit is proposed that cut offs for both measures of obesity should be lower (BMI 23-24.9 kg/m2 for overweight and 25kg/m2 for obesity for south Asians. Median values of Serum insulin of IR>2 were 21.76 and IR 2 were 6.28µU/mL respectively (p<0.001). Regarding serum lipid profile- HDL cholesterol were significantly raised in IR>2 (p<0.005). To clarify the relationship of the changes in insulin resistance, body weight and lipid profile we performed this study in Bangladeshi adult women.
Keywords: Prediction, insulin resistance, ethnic groups.