Smita Roy1, Parimol Kishore Dev2, Begum Nazmus Sama Shimu3, Nasrin Akter4,
Mushfika Rahman Chys5, Umme Asma Mridha6, Umme Fahmida Malik7, Saleha Afrin Bristi8
1. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet.
2. Associate Professor, Department of Anaesthesiology, Jalalabad Ragib Rabeya Medical College, Sylhet
3. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
4. Associate Professor, Department of Pharmacology, North East Medical College, Sylhet
5. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
6. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
7. Professor, Department of Biochemistry, North East Medical College, Sylhet
8. Indoor Medical Officer, Department of Coronary Care Unit, North East Medical College, Sylhet
Abstract
Type 2 diabetes mellitus (T2DM) is associated with a high prevalence of dyslipidemia and poor glycemic control, both of which contribute to an increased risk of cardiovascular complications. This study aimed to evaluate the relationship between lipid abnormalities and glycemic control in T2DM patients in Bangladesh. A cross-sectional study was conducted at Sylhet MAG Osmani Medical College including 150 T2DM patients aged 18 years or older. Data were collected through clinical evaluations and laboratory investigations, including HbAlc and lipid profile measurements. Statistical analyses were performed using SPSS version 26.0, with multivariate regression used to identify significant predictors of glycemic control. The study population had a mean HbAlc of 8.4% (SD ±1.5), with 70% of participants exhibiting poor glycemic control (HbAlc 7%). Dyslipidemia was highly prevalent, with 80% of participants having elevated LDL-C, 70% elevated triglycerides, and 65.33% low HDL-C levels. Multivariate regression analysis identified LDL-C (= 0.015, p < 0.001), triglycerides (= 0.012, p = 0.001), and HDL-C (= -0.022, p=0.002) as significant lipid-related predictors of HbAlc and duration of diabetes (= 0.034, p < 0.001) also significantly influenced glycemic control. Dyslipidemia is strongly associated with poor glycemic control in T2DM patients. The purpose of this study is to integrated management strategies targeting both lipid abnormalities and glycemic control to mitigate cardiovascular risk and improve clinical outcomes.
Key Words: Type 2 diabetes mellitus, Dyslipidemia, HbAlc, Glycemic Control, Lipid Profile, Cardiovascular Risk.