Iqbal Ahmed1, Parimol Kishore Dev2, Nadia Tasnim3, Shahria Raquib Liza4, Smita Roy5
1. Assistant professor, Department of Dermatology and Venereology, Jalalabad Ragib Rabeya Medical College and Hospital, Sylhet
2. Associate professor, Department of Anaesthesia, Jalalabad Ragib Rabeya Medical College Hospital, Sylhet.
3. Registrar, Department of Dermatology and Venereology, Jalalabad Ragib Rabeya Medical College and Hospital, Sylhet
4. Assistant Registrar, Department of Dermatology and Venereology, Jalalabad Ragib Rabeya Medical College and Hospital, Sylhet
5. Assistant professor, Department of Biochemistry, North East Medical College Hospital, Sylhet
Abstract
The term “dermatophytosis” refers to a group of pathogenic fungi called dermatophytes that have a strong affinity for the keratinized tissues found in nails, skin, and hair. There are already a number of antifungal medications available to treat mycoses, yet they have limited cellular targets, and fungus may develop tolerance or resistance to them. An experimental study was conducted at the Jalalabad Ragib Rabeya Medical College and Hospital (JRRMCH) at Sylhet’s Department of Dermatology and Venereology. In total, 100 individuals with resistant dermatophytosis of all sorts participated in this study. Between 18 and 60 years old, patients of both sexes were included. Oral terbinafine 250 mg was administered to each patient twice daily. After three weeks, patients were recommended to follow up. A 51-75% improvement was seen in 45% of patients, while a 76-100% improvement was seen in 30% of patients. Only a small number of patients developed adverse effects (39%). According to our study. treating individuals with resistant dermatophytosis with oral terbinafine in a dose of 250 mg given twice daily was effective and safe.
Key Words: dermatophytosis, dermatophytes, resistance, terbinafine, efficacy, fungus