Md. Abul Khaer Chowdhury1, Mst Tasnim Tabssum Chowdhury2, Jasim Uddin Ahmed3,
Parvej Mia4, Abdullah Sayed5, Nasrin Akter6, Md. Sadequr Rahman7, Md Rahimullah Miah8
1. Assistant Professor, Department of Pharmacology and Therapeutics, North East Medical College, Sylhet
2. Lecturer, Department of Community Medicine, North East Medical College, Sylhet
3. Assistant Professor, Department of Ophthalmology, Chattagram International Medical College Hospital.
4. Register, Department of Medicine, North East Medical College, Sylhet
5. Assistant Professor, Department of Psychiatry, North East Medical College, Sylhet
6. Associate Professor, Department of Pharmacology and Therapeutics, North East Medical College, Sylhet
7. Assistant Professor, Department of Medicine, Parkview Medical College, Sylhet
8. Head, Department of IT in Health, North East Medical College, Sylhet
Abstract
Dilatation and curettage (D&C) is the most common gynaecological procedure that causes significant pain. Use of Propofol as a sedative agent is probably the principle technique for the induction of an anaesthesia for dilatation and curettage, and that may cause cardiovascular and respiratory depression in a dose dependent manner. These unwanted effects of propofol may be reduced when used in association with ketamine. In the study, we compare the adverse effect of propofol and ketamine in respect to the hemodynamic state and recovery times from sedation in D&C. This randomized case -control study was performed on 60 patients, who underwent D&C procedure. Patients, were randomized to propofol (P) and ketamine (K) groups. The heart rate, mean arterial blood pressures and peripheral oxygen saturation were recorded. In recovery room, the pain was assessed by visual analogue scale and the patient’s and surgeon’s satisfactions were assessed by Aldrete scoring system and post anaesthesia discharge scoring system. Demographic data were found similar in two groups. There were no remarkable differences in heart rate and arterial blood pressures in all time intervals among groups. Recovery time was remarkably increased in Group P compared to Group K. Aldrete score at 5th minute was statistically decreased in Group P though visual analogue scale at 5th and 10 minute were statistically increased in this Group. There was no notable difference among groups in regard to satisfaction scores. According to our study, Ketamine and propofol has a shorter mean orientation time with similar hemodynamic stability and satisfaction scores in D&C procedure.
Key Words: D & C, propofol, ketamine.