Begum Nazmus Sama Shimu1, Md. Saiful Islam Bhuiyan2, Tarun Kanti Paul3, Smita Roy4, Mushfika Rahman Chy5, Umme Asma Mridha6, Umme Fahmida Malik7
1. Assistant professor, Department of Biochemistry, North East Medical College, Sylhet, Bangladesh.
2. Associate professor and Head, Department of Psychiatry, Mainamoti Medical College, Comilla, Bangladesh
3. Lecturer, Department of Microbiology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
4. Assistant professor, Department of Biochemistry, North East Medical College, Sylhet, Bangladesh.
5. Assistant professor, Department of Biochemistry, North East Medical College, Sylhet, Bangladesh.
6. Assistant professor, Department of Biochemistry, North East Medical College, Sylhet, Bangladesh
7. Professor and Head, Department of Biochemistry, North East Medical College, Sylhet, Bangladesh
Abstract
Ferritin is the storage form of won, and serum ferritin levels are widely applied as an indicator of iron status. The amount of ferritin in circulation normally reflects the amount of iron stored in the body in healthy individuals. Metabolic syndrome (MetS), is a pathophysiologic state, recognized by elevated serum glucose, hypertension, abdominal obesity, and hyperlipidemia. The purpose of this study was to take a gender into the relationship between serum ferritin levels and metabolic syndrome. In total, 90 participants were included in this study Among them, 45 patients who had metabolic syndrome as diagnosed by the International Diabetes Federation (IDF) criteria were considered as cases and 45 healthy individuals as controls within the age limit between 25-65yrs were included. Anthropometric measurements like height, weight, waist circumference were measured Blood pressure was measured and blood investigations were sent for lipid profile, fasting blood glucose levels, and serum ferritin. The purposive sampling method was used Mean BMI. fasting blood glucose, systolic blood pressure (mm Hg), diastolic blood pressure (mm Hg) and serum ferritin (ng/mL) were found 26.71 ±1.56. 146.84±22.28. 138.44±13.17, 86.67±10.33, 198.29±69.13 respectively in case groups. However in control groups Mean BMI. Fasting blood glucose, systolic blood pressure (mm Hg), diastolic blood pressure (mm Hg) and Serum ferritin (ng/mL) were found to be 23.33±2.17, 102.06+25.77. 111.67±13.27, 73.33±10.22 and 182.46±177.03 respectively. Serum ferritin level was positively correlated with HDL-C, systolic BP, and triglyceride among the study population. From the findings of our study, we can conclude that Serum ferritin levels are elevated in patients with metabolic syndrome and it may be one of the key factors that contribute to the progression of metabolic syndrome to Type II DM and other cardiometabolic disorders.
Key Words: Serum Ferritin, Metabolic Syndrome (MetS), Body Mass Index (BMI), Type 2 DM.