Umme Asma Mridha1, Md.Shahadat Hossain2, Bidhan Chandra Debnath3, Monojit Mojumder4,
Md. Saiful Islam Bhuiyan5
Md. Saiful Islam Bhuiyan5
1. Asistant Profesor (CC), Physiology, Northeast Medical College, Sylhet.
2. Profesor & Head, Biochemistry, Sylhet M.A.G Osmani Medical College, Sylhet.
3. Profesor & Head, Biochemistry, Park View Medical College, Sylhet.
4. Associate Profesor, Biochemistry, Sylhet M.A.G Osmani Medical College, Sylhet.
5. Asistant Profesor, Psychiatry, Mainamoti Medical College, Comilla.
Abstract
Thyroid physiology changed significantly during gestation. Interpretation of thyroid function tests in pregnancy depend on gestational age considering normal physiological changes. It was not unusual to encounter thyroid function abnormalities during a “routine” laboratory evaluation carried out for pregnant women. Uncorrected thyroid dysfunction in pregnancy may have adverse effects on maternal and fetal well being and may affect neuro-intellectual development in early life of a child. To evaluate the maternal thyroid status in different trimesters of normal pregnancy. This prospective longitudinal observational study was carried out in the department of Biochemistry, Sylhet MAG Osmani Medical College during the period from July 2013 to June 2014. 45 pregnant women in first trimester of pregnancy of 18-40 years of age were selected. Maternal blood pressure, BMI, serum TSH, free thyroxin (FT4) were measured. Patients were followed up throughout the 2nd and 3rd trimesters. Serum total protein and random blood glucose were also estimated. Thirty (30) pregnant women completed all three trimesters visit. Serum TSH was 0.88 ± 0.64 mIU/ml, 0.98 ± 0.59 mIU/ml and 0.86 ± 0.69 mIU/ml in first, second and third trimesters respectively. No significant difference was observed between first and third trimester (p=0.898); second and third trimester (p=0.486); and first and second trimester (p=0.490). Serum free T4 was 19.70±4.49 pmol/L, 19.94 ± 3.80 pmol/L and 21.22 ± 7.99 pmol/L in first, second and third trimesters. No significant difference in serum free T4 level between first and third trimester (p=0.361), second and third trimester (p=0.399); and first and second trimester (p=0.800). Serum TSH and free T4 rise non-significantly throughout first, second and third trimesters of pregnancy. This study showed a trend of change of thyroid hormones and TSH during normal pregnancy.
Keywords: Thyroid Status, Normal Pregnancy