Chowdhury Mushfika Rahman1, F.M.A Md. Musa Chowdhury2, Chowdhury Tawhida Rahman3, Begum Nazmus Sama Shimu4, Md. Kamrul Husain Azad5,
Syeda Umme Fahmida Malik6, Md. Shahadat Hossain7
1. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
2. Associate Professor, Department of Transfusion Medicine, Sylhet MAG Osmani Medical College, Sylhet
3. Assistant Professor, Department of Biochemistry, Comilla Army Medical College, Comilla
4. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
5. Assistant Professor, Department of Biochemistry, North East Medical College, Sylhet
6. Associate Professor, Department of Biochemistry, North East Medical College, Sylhet
7. Professor and Head, Department of Biochemistry, Sylhet MAG Osmani Medical College, Sylhet
Abstract
Prevalence to thyroid dysfunction is increased in type 2 diabetic population and also the fact that thyroid auto-antibodies could potentially identify subject at risk of thyroid dysfunction. The study was case-control comparative study, conducted at Sylhet MAG Osmani Medical College in collaboration with Sylhet Diabetic Hospital & Nuclear Medicine and Allied Sciences Centre, Sylhet, Bangladesh to investigate thyroid autoimmunity in type 2 DM patients of Bangladesh.
A random sample of 75 type 2 diabetics was studied from Sylhet Diabetic Hospital and age-sex matched 75 healthy controls were studied from general population. Antibody markers thyroperoxidase (Anti-TPO) & thyroglobulin (Anti-Tg) were measured by RIA kit (Beijing Atom High Techno Co, Ltd, China) and thyroid status by thyroid stimulating hormone TSH levels by IRMA kit (Beijing Atom High Techno Co, Ltd, China) in Nuclear Medicine & Allied Sciences Centre, Sylhet. Among 75 type 2 diabetic subjects, 5 (6.7%) had positive Anti-TPO & Tg-Ab levels. Thyroid autoimmunity were detected in 6.7% type 2 diabetics vs 0% in controls (p<0.05). The mean age of cases was 51.91±8.97 years, mean duration of diabetes was 7.69±3.24 years, mean HbAlc level 7.45±1.01% but there was no correlation of thyroid auto-antibodies with duration of diabetes. Thyroid stimulating hormone (TSH) did not differ significantly between cases & controls.
Our findings demonstrate that a few type 2 DM patients had positive anti-thyroperoxidase and anti-thyroglobulin levels. It may be concluded from this study that thyroid autoimmunity may be associated with type 2 DM. So thyroid antibody levels and thyroid function tests may be considered in those patients. Further studies are required with relatively larger study population, FT3 & FT4 analyses with multicentre involvement and in addition to these, HLA gene typing of these patients are also needed for better understanding of this association.
Key words: Type 2 diabetes, Thyroid antibodies (Anti-TPO & Tg-Ab), TSH